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Research

PRAXIS is a research group first and an events organization second. These projects define the intellectual agenda. Members join an existing project or propose their own at the monthly pitch session.

Vocal Biomarkers — crossbenching anhedonia

IdeaAnalysisPreprintReviewPublishedActive

Extracting acoustic and semantic biomarkers of anhedonia from spontaneous speech using ClinicalWhisper. By crossbenching anhedonia against computational phenotypes, the next step is integrating large language models with reinforcement learning to model reward-prediction errors in vocal flat affect.

LLM + RLAudio processingClinical data

ClinicalWhisper

IdeaAnalysisPreprintReviewPublishedPreprint → journal

A speech model adapted for clinical interview audio, and the tool the group is furthest along on building. A preprint was posted to bioRxiv in June 2026; the work is being prepared for peer-reviewed submission alongside continued validation.

Speech modelsReproducible pipelineOpen source

Zhou, C., Wu, M., Xiang, Y., & Itti, L. (2026). Cross-modal benchmarking of acoustic prosody and ventral striatal BOLD for depression-related anhedonia classification: A pre-registered study with the ClinicalWhisper pipeline. bioRxiv. doi:10.64898/2026.06.08.728970

fMRI benchmark analysis

IdeaAnalysisPreprintReviewPublishedOngoing

A parallel analysis track benchmarking computational phenotypes against functional imaging data, run alongside the voice work.

NeuroimagingBenchmarking